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KMID : 0877220090130010027
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Journal of Korean Epilepsy Society
2009 Volume.13 No. 1 p.27 ~ p.30
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A Case of Carbamazepine-Induced Peripheral Neuropathy
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Lee Sang-Yoon
Koh Eun-Sil
Kim Kee-Won
Jung Se-Hee
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Abstract
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Peripheral neuropathy is rarely caused by antiepileptic drugs and most cases were reported about phenytoin. Here we report carbamazepine-induced peripheral neuropathy, which is a very rare condition and the pathogenesis is not well understood. A 19-year-old man presented with a several-year history of bilateral foot pain and pesplanus. He had craniopharyngioma and underwent neurosurgery in 1997 and 2007. He had been prescribed by the general dose (600 mg/day) of carbamazepine since 1998 for the treatment of postoperative epilepsy. His muscle power was normal in all limbs and there were no abnormal sensory symptom and sign. Findings of electrodiagnostic studies were compatible with sensorimotor polyneuropathy with mixed axonotmesis and demyelination. His family history and genetic diagnosis excluded the possibility of hereditary neuropathy. After dose reduction of carbamazepine, his bilateral foot pain has been improved slowly. We report a case of carbamazepine-induced peripheral neuropathy.
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KEYWORD
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Antiepileptics, Carbamazepine, Drug induced neuropathy
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